RT Journal Article
SR Electronic
T1 Effect of Guselkumab and IL-17 Inhibitors on Work Productivity and Activity Impairment in Psoriatic Arthritis: 6-Month Results of the PsABIOnd Observational Study
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 120
OP 121
DO 10.3899/jrheum.2026-0447.142
VO 53
IS Suppl 1
A1 Rahman, Proton
A1 Siebert, Stefan
A1 Sharaf, Mohamed
A1 Behrens, Frank
A1 Kishimoto, Mitsumasa
A1 Soriano, Enrique
A1 Rampakakis, Emmanouil
A1 Köleséri, László
A1 Lozenski, Karissa
A1 Silva, Ruben Queiro
A1 Lubrano, Ennio
A1 Gossec, Laure
YR 2026
UL http://www.jrheum.org/content/53/Suppl_1/120.2.abstract
AB Objectives Work impairment is a key issue in PsA. Biologic treatments can improve work status in patients with PsA; however, there is lack of comparative real-world data for different classes, eg, IL-23 and IL-17 inhibitors(i). The current analysis aimed to assess PsA patient-reported outcomes (PRO), specifically work productivity, activity impairment, and disease impact after 6 months of treatment with guselkumab (GUS) and IL-17i.Methods PsABIOnd (NCT05049798) is a global observational study in PsA patients starting GUS or IL17i as 1st-to-4th line of biologic therapy per standard of care.[1] Here, the full population of the PsABIOnd study was analyzed over the first 6 months of follow-up. Work productivity and activity impairment were assessed via the Work Productivity and Activity Impairment Questionnaire (WPAI; 0-100).[2] Patient-reported disease impact was assessed using the PsA Impact of Disease-12 (PsAID12; 0-10),[3] including the mean total score and proportions of pts achieving minimal clinically important improvement (MCII); improvement by ≥1.4; among pts with BL PsAID-12 score ≥1.4). All analyses were performed according to initial treatment group allocation, and treatment comparison was based on 95% confidence intervals (CI).Results 1134 patients were analyzed; 555 and 579 received GUS or IL-17i, respectively, as their initial treatment. Mean age (53.2/53.5 yrs), sex (60.4%/59.2% female), and prior exposure to a targeted drug (63.4%/62.3%) were comparable for GUS/IL-17i. Mean overall baseline work productivity loss (42.3%/44.5% for GUS/IL17i groups), absenteeism (14.3%/12.9%), presenteeism (39.2%/42.1%), activity impairment (48.5%/50.6%), and mean baseline PsAID-12 total score (5.1/5.1) were also similar between groups. At the 6-month visit, comparable improvements were observed in all WPAI outcomes with GUS and IL-17i. Mean (95% CI) improvements in GUS/IL-17i were: overall work productivity loss (−13.1 [−16.5, −9.7]/−13.8 [−17.5, −10.1]%), absenteeism (−6.4 [−10.4, −2.4]/−2.5 [−5.1, 0.2]%), presenteeism (−12.5 [−15.7, −9.3]/−14.0 [−17.5, −10.5]%), activity impairment (−13.1 [−15.4, −10.8]/−15.7 [−18.2, −13.1]%); (Figure 1). Mean PsAID-12 total scores also improved significantly (−1.6 [−1.7, −1.4]/−1.8 [−2.0, −1.6]) reaching levels (3.5/3.3) indicative of symptom impact below the patient acceptable symptom state threshold (≤ 4.0) in both groups. Rates of pts achieving PsAID-12 MCII at 6 months were also comparable (54.7%/55.9%).Conclusion By 6 months of treatment in real-world, improvements in work productivity and ability to perform daily activities were observed with both GUS and IL-17i, paralleled with clinically meaningful improvements in patient-reported multidomain disease impact. Based on overlapping CIs, improvements in PROs were comparable between the 2 classes. These results may be useful for reimbursement decisions and healthcare provider/patient shared treatment decision-making.References [1.] Siebert S. Rheumatol Ther 2023;10:489. [2.] Teilly MC. Parmacoeconomics. 1993;4:353. [3.] Gossec L. Ann Rheum Dis 2014;73:1012.