<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kılbaş, Gülşah</style></author><author><style face="normal" font="default" size="100%">Ayduran, Semra</style></author><author><style face="normal" font="default" size="100%">Şener, Seher</style></author><author><style face="normal" font="default" size="100%">Coşkuner, Taner</style></author><author><style face="normal" font="default" size="100%">Ulu, Kadir</style></author><author><style face="normal" font="default" size="100%">Kısaoğlu, Hakan</style></author><author><style face="normal" font="default" size="100%">Aslan, Esma</style></author><author><style face="normal" font="default" size="100%">Kılıç Könte, Elif</style></author><author><style face="normal" font="default" size="100%">Arslanaoğlu, Ceyda</style></author><author><style face="normal" font="default" size="100%">Aydın, Tuncay</style></author><author><style face="normal" font="default" size="100%">Şadırvan Oğuzkaya, Yağmur</style></author><author><style face="normal" font="default" size="100%">Çakmak, Figen</style></author><author><style face="normal" font="default" size="100%">Gezgin Yıldırım, Deniz</style></author><author><style face="normal" font="default" size="100%">Kaplan, Melike Mehveş</style></author><author><style face="normal" font="default" size="100%">Tiğrak, Saadet Nilay</style></author><author><style face="normal" font="default" size="100%">Türkuçar, Serkan</style></author><author><style face="normal" font="default" size="100%">Sönmez, Hafize Emine</style></author><author><style face="normal" font="default" size="100%">Kışla Ekinci, Miray</style></author><author><style face="normal" font="default" size="100%">Öztürk, Kübra</style></author><author><style face="normal" font="default" size="100%">Demir, Ferhat</style></author><author><style face="normal" font="default" size="100%">Bağlan, Esra</style></author><author><style face="normal" font="default" size="100%">Bozkaya, Burcu</style></author><author><style face="normal" font="default" size="100%">Taşkın, Sema Nur</style></author><author><style face="normal" font="default" size="100%">Demir, Selcan</style></author><author><style face="normal" font="default" size="100%">Sağ, Erdal</style></author><author><style face="normal" font="default" size="100%">Deniz Batu, Ezgi</style></author><author><style face="normal" font="default" size="100%">Şahin, Sezgin</style></author><author><style face="normal" font="default" size="100%">Bakkaloğlu Ezgü, Sevcan A.</style></author><author><style face="normal" font="default" size="100%">Kılıc, Sara Sebnem</style></author><author><style face="normal" font="default" size="100%">Paç Kısaarslan, Ayşenur</style></author><author><style face="normal" font="default" size="100%">Çelikel Acar, Banu</style></author><author><style face="normal" font="default" size="100%">Kalyoncu, Mukaddes</style></author><author><style face="normal" font="default" size="100%">Ayaz, Nuray Aktay</style></author><author><style face="normal" font="default" size="100%">Sözeri, Betül</style></author><author><style face="normal" font="default" size="100%">Ünsal, Erbil</style></author><author><style face="normal" font="default" size="100%">Kasapçopur, Özgür</style></author><author><style face="normal" font="default" size="100%">Özen, Seza</style></author><author><style face="normal" font="default" size="100%">Yüksel, Selçuk</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Results of a Nationwide Multicenter Study in Childhood Sjögren Disease</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Rheumatology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2025-07-15 04:00:18</style></date></pub-dates></dates><elocation-id><style  face="normal" font="default" size="100%">jrheum.2024-1048</style></elocation-id><doi><style  face="normal" font="default" size="100%">10.3899/jrheum.2024-1048</style></doi><volume><style face="normal" font="default" size="100%"></style></volume><issue><style face="normal" font="default" size="100%"></style></issue><abstract><style  face="normal" font="default" size="100%">Objective This nation-wide, multicenter study was conducted to assess the demographic, clinical features, treatment regimens, and prognosis of primary Sjögren disease (SjD) in childhood.Methods This retrospective study included a total of 81 patients under 18 years of age from 21 pediatric rheumatology centers. Among these, 51 patients fulfilled the diagnosis of childhood SjD strictly according to the 2016 ACR/EULAR classification criteria. The remaining 30 patients, who did not fully meet these criteria but exhibited clinical and laboratory findings suggestive of SjD, were categorized as 'at-risk for childhood SjD' to highlight diagnostic challenges and spectrum of early presentations, based on comprehensive clinical evaluation by experienced pediatric rheumatologists.Results The cohort consisted of 81 patients (85.2% female, 14.8% male) with a median age at symptom onset of 11.4 years and a median follow-up of 24 months. Common clinical manifestations included dry mouth, dry eyes, arthralgia, fatigue, and parotitis. Fifty-one of the 81 patients met the 2016 ACR/EULAR classification criteria, while the remaining 30 were classified as an at-risk group. The most common clinical findings in 30 patients 'at-risk group' were xerostomia (90%), arthralgia (56.7%), fatigue (50%), and dry eyes (43.3%). Dry mouth, and peripheral nervous system involvements were found to be higher in patients categorized as at-risk (p = 0.03, p = 0.02, respectively).Conclusion The current classification criteria for childhood SjD appear to be inadequate, highlighting the need for pediatric-specific criteria that more accurately reflect the distinct clinical patterns observed in children.</style></abstract></record></records></xml>