RT Journal Article
SR Electronic
T1 What Is Allopurinol Failure and What Should We Do About It?
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 556
OP 562
DO 10.3899/jrheum.2024-0144
VO 51
IS 6
A1 Stamp, Lisa K.
A1 Dalbeth, Nicola
YR 2024
UL http://www.jrheum.org/content/51/6/556.abstract
AB Allopurinol is the most widely used urate-lowering medication worldwide. However, allopurinol failure is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol failure, which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol failure underpins the approach required to turn failure into success in gout management.