PT  - JOURNAL ARTICLE
AU  - Sergey Moiseev
AU  - Nikolay Bulanov
AU  - Matija Crnogorac
AU  - Haner Direskeneli
AU  - Kresimir Galesic
AU  - Ummugulsum Gazel
AU  - Duvuru Geetha
AU  - Loic Guillevin
AU  - Zdenka Hrušková
AU  - Mark A. Little
AU  - Liam O'Neill
AU  - Egor Makarov
AU  - Stephen P. McAdoo
AU  - Aladdin J. Mohammad
AU  - Sarah Moran
AU  - Pavel Novikov
AU  - Charles D. Pusey
AU  - Chinar Rahmattulla
AU  - Veronika Satrapová
AU  - Joana Silva
AU  - Alexander Suvorov
AU  - Vladimír Tesar
AU  - Benjamin Terrier
AU  - Peter Willeit
AU  - Ming-Hui Zhao,
Andreas Kronbichler
AU  - David R.W. Jayne
TI  - Traditional and Disease-Specific Risk Factors for Cardiovascular Events in ANCA-Associated Vasculitis: A Multinational Retrospective Study
AID  - 10.3899/jrheum.220851
DP  - 2023 Jan 15
TA  - The Journal of Rheumatology
PG  - jrheum.220851
4099  - http://www.jrheum.org/content/early/2023/06/02/jrheum.220851.1.short
4100  - http://www.jrheum.org/content/early/2023/06/02/jrheum.220851.1.full
AB  - Objective To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods Patients with a definite diagnosis of AAV who were followed for ≥ 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. Conclusion We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.