RT Journal Article
SR Electronic
T1 Traditional and Disease-Specific Risk Factors for Cardiovascular Events in ANCA-Associated Vasculitis: A Multinational Retrospective Study
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.220851
DO 10.3899/jrheum.220851
A1 Sergey Moiseev
A1 Nikolay Bulanov
A1 Matija Crnogorac
A1 Haner Direskeneli
A1 Kresimir Galesic
A1 Ummugulsum Gazel
A1 Duvuru Geetha
A1 Loic Guillevin
A1 Zdenka Hrušková
A1 Mark A. Little
A1 Liam O'Neill
A1 Egor Makarov
A1 Stephen P. McAdoo
A1 Aladdin J. Mohammad
A1 Sarah Moran
A1 Pavel Novikov
A1 Charles D. Pusey
A1 Chinar Rahmattulla
A1 Veronika Satrapová
A1 Joana Silva
A1 Alexander Suvorov
A1 Vladimír Tesar
A1 Benjamin Terrier
A1 Peter Willeit
A1 Ming-Hui Zhao,
Andreas Kronbichler
A1 David R.W. Jayne
YR 2023
UL http://www.jrheum.org/content/early/2023/06/02/jrheum.220851.abstract
AB Objective To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods Patients with a definite diagnosis of AAV who were followed for ≥ 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. Conclusion We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.