RT Journal Article
SR Electronic
T1 Differential Effects of Integrin Blockade on Gut and Sacroiliac Joint Inflammation
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.2022-1272
DO 10.3899/jrheum.2022-1272
A1 Zoya Qaiyum
A1 Michael Tang
A1 Pablo Andres Olivera
A1 Robert Davies Inman
YR 2023
UL http://www.jrheum.org/content/early/2023/05/10/jrheum.2022-1272.abstract
AB α4β7 is a prototypic gut integrin that regulates homing of memory and effector T cells to the gut.1 Vedolizumab is an anti-α4β7 monoclonal antibody and is approved by the US Food and Drug Administration to treat ulcerative colitis and Crohn disease (CD). 1