TY - JOUR T1 - Isolated Neutropenia in Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol SP - 459 LP - 460 DO - 10.3899/jrheum.220373 VL - 50 IS - 3 AU - Nouf A. Alhammadi AU - Dafna D. Gladman AU - Jiandong Su AU - Murray B. Urowitz Y1 - 2023/03/01 UR - http://www.jrheum.org/content/50/3/459.abstract N2 - To the Editor:Lymphopenia is the most commonly found leukocyte abnormality in patients with systemic lupus erythematosus (SLE). Neutropenia prevalence varied from 20% to 40% in a systematic literature review.1 Most of the neutropenia episodes occurring in patients with SLE are mild, but approximately 5% of patients may experience moderate (≥ 500/mm3 ≤ absolute neutrophil count [ANC] < 1000/mm3) to severe neutropenia (ANC < 500/mm3).2 The proposed pathogenesis of neutropenia in SLE includes increased peripheral destruction of granulocytes by circulating antineutrophil antibodies,3 increased margination or changes in marginal and splenic pool,4 and decreased granulocytopoiesis in the bone marrow.5,6Isolated neutropenia might be benign in certain ethnicities7; however, its role … ER -