RT Journal Article SR Electronic T1 Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 433 OP 437 DO 10.3899/jrheum.220313 VO 50 IS 3 A1 Dhruvkumar Laheru A1 Anna Antony A1 Sueli Carneiro A1 Vito Di Lernia A1 Amit Garg A1 Thorvardur Jon Love A1 Karla del Rocio Macias Garcia A1 José Alexandre Mendonça A1 Sandeep Mukherjee A1 Rodica Olteanu A1 Lourdes Perez-Chada A1 Cheryl F. Rosen A1 Rachel Tannenbaum A1 Michel Alexandre Yazbek YR 2023 UL http://www.jrheum.org/content/50/3/433.abstract AB Objective Nail psoriasis is common, impairs fine motor finger functioning, affects cosmesis, and is associated with a lower quality of life. This review updates the previous Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for nail psoriasis.Methods This systematic literature review of the PubMed, MEDLINE, Embase, and Cochrane databases examined the updated evidence since the last GRAPPA nail psoriasis treatment recommendations published in 2014. Recommendations are based on preformed PICO (Patient/Population - Intervention - Comparison/Comparator - Outcome) questions formulated by an international group of dermatologists, rheumatologists, and patient panel members. Data from this literature review were evaluated in line with Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology.Results Overall, there is insufficient evidence to make any recommendation for the use of topical corticosteroids, topical calcipotriol, topical tazarotene, topical cyclosporine, dimethyl fumarates/fumaric acid esters, phototherapy, and alitretinoin. There is a low strength of evidence to support the use of calcipotriol and corticosteroid preparations, topical tacrolimus, oral cyclosporine, oral methotrexate, intralesional corticosteroids, pulsed dye laser, acitretin, Janus kinase inhibitors, and apremilast.Conclusion The highest strength of supporting evidence is for the recommendation of biologic agents including tumor necrosis factor inhibitors, and interleukin 12/23, 17, and 23 inhibitors.