RT Journal Article SR Electronic T1 Work-Related Issues and Physical and Psychological Burden in Canadian Patients With Axial Spondyloarthritis: Results From the International Map of Axial Spondyloarthritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.220596 DO 10.3899/jrheum.220596 A1 Robert D. Inman A1 Marco Garrido-Cumbrera A1 Jonathan Chan A1 Martin Cohen A1 Artur J. de Brum-Fernandes A1 Wendy Gerhart A1 Nigil Haroon A1 Algis V. Jovaisas A1 Gerald Major A1 Michael G. Mallinson A1 Sherry Rohekar A1 Patrick Leclerc A1 Proton Rahman YR 2022 UL http://www.jrheum.org/content/early/2023/01/25/jrheum.220596.abstract AB Objective To identify factors associated with work-related issues in Canadian patients with axial spondyloarthritis. Methods Data from 542 Canadian patients who participated in the International Map of Axial Spondyloarthritis online survey were analyzed. Participants who were employed, unemployed, or on short-term disability were included in this analysis. Regression analysis was used to study the association between work-related issues, disease activity (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]), and psychological distress (12-item General Health Questionnaire [GHQ-12]). Results The mean age of surveyed participants was 44.3 (SD 13.9) years, 81% were university educated, and 52.6% employed. A substantial proportion had high disease activity (BASDAI ≥ 4, 72.1%) and psychological distress (GHQ-12 ≥ 3, 53.1%); 81% had work-related issues. This study analyzed responses from a subset of participants who were either employed, unemployed, or on short-term disability (n = 339). Ninety percent of this subset reported at least 1 work-related issue in the year before questionnaire completion, with the most frequent being absenteeism (49.3%) and missing work for healthcare provider visits (42.5%). Factoring in disability benefits eliminated the association between work-related issues and disease activity for all variables except fatigue (r = 0.217; P = 0.03) and discomfort (r = 0.196; P = 0.047). Difficulty fulfilling working hours (β 2.342, 95% CI 1.413-3.272) and effect on professional advancement (β 1.426, 95% CI 0.355-2.497) were associated with psychological distress. In the presence of disability benefits, only the effect on professional advancement remained (β 2.304, 95% CI 0.082-4.527). Conclusion Work-related issues are associated with worse patient-reported outcomes, both physical and psychological.