RT Journal Article
SR Electronic
T1 Sleep and Sleep Complaints in Juvenile Fibromyalgia Syndrome
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.220720
DO 10.3899/jrheum.220720
A1 Clara Malattia
A1 Lorenzo Chiarella
A1 Miriam Sansone
A1 Angela Pistorio
A1 Claudio Lavarello
A1 Manuela Carpaneto
A1 Raffaele Ferri
A1 Angelo Ravelli
A1 Lino Nobili
YR 2023
UL http://www.jrheum.org/content/early/2023/01/10/jrheum.220720.abstract
AB Objective To investigate sleep quality in juvenile fibromyalgia syndrome (JFS) and its impact on the global burden of the disease. Methods Consecutive JFS patients who performed full-night polysomnography (PSG) were included in this cross-sectional study. JFS related symptoms, neuropsychiatric features, and sleep quality were assessed using self-report measures. PSG sleep parameters, including N3 distribution index, were obtained from patients and age-matched healthy controls. Results We included 25 patients (F 20, median age 15.7 years). Non restorative sleep was reported by 22/25 (88%) patients. JFS patients showed significantly longer Sleep Period Time (P=0.004) and increased wake time after sleep onset (P=0.03) compared to healthy peers. N3 sleep distribution index was significantly lower in patients than in control group (P=0.02). Subjective poor sleep quality was related to Widespread Pain Index (WPI) (rs-0.65), symptom severity scale (rs-0.64), depressive symptoms (rs-0.58), fatigue (rs-0.44), and symptoms severity upon awakening (rs-0.65). N3 distribution index was correlated to depressive symptoms (rs 0.41) and irritability (rs 0.40). On multiple regression analysis, WPI was predicted by subjective sleep quality (β= -0.32, P=0.04), whereas depressive symptoms were predicted by subjective sleep measures (β= -0.32, P= 0.04) and PSG parameters (N3 min: β= -0.07, P=0.03). Conclusion Sleep complaints are a key hallmark of JFS and has significant impact on relevant clinical domains of the disease, such as pain and depression.