PT - JOURNAL ARTICLE AU - Sergey Moiseev AU - Nikolay Bulanov AU - Matija Crnogorac AU - Haner Direskeneli AU - Kresimir Galesic AU - Ummugulsum Gazel AU - Duvuru Geetha AU - Loic Guillevin AU - Zdenka Hrušková AU - Mark A. Little AU - Liam O'Neill AU - Egor Makarov AU - Stephen P. McAdoo AU - Aladdin J. Mohammad AU - Sarah Moran AU - Pavel Novikov AU - Charles D. Pusey AU - Chinar Rahmattulla AU - Veronika Satrapová AU - Joana Silva AU - Alexander Suvorov AU - Vladimír Tesar AU - Benjamin Terrier AU - Peter Willeit AU - Ming-Hui Zhao AU - Andreas Kronbichler AU - David R. W. Jayne TI - Traditional and disease specific risk factors for cardiovascular events in ANCA-associated vasculitis: a multinational retrospective study AID - 10.3899/jrheum.220851 DP - 2023 Jan 15 TA - The Journal of Rheumatology PG - jrheum.220851 4099 - http://www.jrheum.org/content/early/2023/01/10/jrheum.220851.short 4100 - http://www.jrheum.org/content/early/2023/01/10/jrheum.220851.full AB - Objective To investigate the occurrence of cardiovascular events (CVE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, China, Turkey, Russia, UK, and USA. Methods Patients with a definite diagnosis of AAV who were followed ≥3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results Over a median follow-up of 62 (interquartile range: 23, 100) months, CVE (mostly MI) occurred in 245 (10.7%) of 2286 AAV patients with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 years; HR 2.93, 95% CI: 1.99, 4.31), smoking (HR 1.98, 95% CI: 1.48, 2.64), Chinese origin (HR 4.24, 95% CI: 3.07, 5.85), pulmonary (HR 1.50, 95% CI: 1.09, 2.06) and kidney (HR 3.02, 95% CI: 2.08, 4.37) involvement were independent variables associated with a higher occurrence of CVE. Conclusion We showed that geographic region and both traditional and disease specific (kidney involvement in particular) factors were independently associated with CVE. Proper assessment and management of modifiable cardiovascular risk factors are essential for prevention of cardiovascular morbidity in AAV patients.