TY - JOUR T1 - Obstacles in Early Diagnosis of Children With Juvenile Idiopathic Arthritis: A Nationwide Israeli Retrospective Study JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.220359 SP - jrheum.220359 AU - Yochai Frenkel AU - Irit Kraushar AU - Mohamad Hamad Saied AU - Ruby Haviv AU - Yosef Uziel AU - Merav Heshin-Bekenstein AU - Eduard Ling AU - Gil Amarilyo AU - Liora Harel AU - Irit Tirosh AU - Shiri Spielman AU - Yackov Berkun AU - Yonatan Butbul Aviel Y1 - 2022/12/01 UR - http://www.jrheum.org/content/early/2023/01/10/jrheum.220359.abstract N2 - Objective Characterization of the stages that patients with juvenile idiopathic arthritis (JIA) pass until they are diagnosed, and analysis of the different causes that lead to a delay in JIA diagnosis in Israel. Methods This is a retrospective cohort study conducted in 8 pediatric rheumatology centers in Israel. All patients diagnosed with JIA between October 2017 and October 2019 were included in the study. Demographic, clinical, and data regarding the referring physicians were collected from hospital and community medical charts. Results Of 207 patients included in the study, 201 cases were analyzed, 71.1% of the population were female. Patients, on average, were evaluated during the diagnostic process by 3.1 different physicians. In most cases, they initially met with a pediatrician in the community setting (61.2%), and later, most commonly referred to a rheumatologist by the community pediatrician (27.9%). The median time until diagnosis was 56.0 days (range: 1.0-2451.0 days). Patients diagnosed with polyarticular and spondyloarthritis/enthesitis-related arthritis (SpA/ERA) JIA subtypes had the longest period until diagnosis (median: 115.5 and 112.0 days, respectively). Younger age correlated with a quicker diagnosis, and females were diagnosed earlier compared to males. Fever at presentation significantly shortened the time to diagnosis (P < 0.01), whereas involvement of the small joints/sacroiliac joints significantly lengthened the time (P < 0.05). Conclusion This is the first nationwide multicenter study that analyzes obstacles in the diagnosis of JIA in Israel. Raising awareness about JIA, especially for patients with SpA/ERA, is crucial in order to avoid delays in diagnosis and treatment. ER -