TY - JOUR T1 - Sex Effect in Psoriatic Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 159 LP - 160 DO - 10.3899/jrheum.220948 VL - 50 IS - 2 AU - Dafna D. Gladman Y1 - 2023/02/01 UR - http://www.jrheum.org/content/50/2/159.abstract N2 - Psoriatic arthritis (PsA) is an inflammatory disease that affects as many as 30% of patients with psoriasis, an immune-mediated inflammatory skin condition. Several domains are recognized in PsA, including peripheral arthritis, axial disease, enthesitis, dactylitis, and skin and nail manifestations.1 Although PsA affects men and women equally, there may be a sex influence on the development and expression of the disease.2 In the past few decades, there has been increasing interest in the effect of sex on the manifestations and impact of PsA as well as on the response to therapy. There may be some genetic reasons. For example, a paternal transmission was noted in PsA.3 The role of female hormones has not been confirmed because although some studies suggested that women with PsA had low pregnancy rates, this was not observed in a recent study.4,5A difference in axial disease expression between men and women was noted in a 1992 study that compared 82 women with 112 men with axial disease and showed that there was more advanced disease in men.6 Similar observations were reported by Queiro et al, who found that axial disease together with HLA-B27 occurred more commonly among men, whereas women had more … Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, University Health Network, 399 Bathurst Street, 1E410B, Toronto, ON M5T 2S8, Canada. Email: dafna.gladman{at}utoronto.ca. ER -