TY - JOUR T1 - Keep It in Mind: Assessing the Risk of Dementia in Patients With Rheumatoid Arthritis and Opportunities for Intervention JF - The Journal of Rheumatology JO - J Rheumatol SP - 3 LP - 5 DO - 10.3899/jrheum.220991 VL - 50 IS - 1 AU - Sebastian E. Sattui AU - Sarah B. Lieber Y1 - 2023/01/01 UR - http://www.jrheum.org/content/50/1/3.abstract N2 - Chronic systemic inflammation contributes directly to increased cardiovascular disease (CVD) burden in patients with rheumatoid arthritis (RA).1 In addition, chronic systemic inflammation is believed to play an important role in the development of other aging-related conditions, including cognitive impairment and dementia.2 Aging-related chronic systemic inflammation, also known as inflammaging, and neuroinflammation are increasingly recognized as central to the pathogenesis of neurodegenerative diseases such as Alzheimer dementia. Although results are not uniform across studies, an increased risk of dementia in adults with RA, when compared to age-matched comparators, has been reported in several epidemiological studies.3 The magnitude of this risk varies across studies, and according to one recent study from the Rochester Epidemiological Project (REP), increased risk has declined over time, narrowing the gap between adults with and without RA.4In this issue of The Journal of Rheumatology, Kodishala et al present the results of a retrospective population-based cohort study assessing risk factors for incident dementia in adults with RA from the REP.5 The REP includes granular data on participants, including diagnosis, comorbid conditions, and treatments, as well as important disease features such as clinical characteristics (eg, erosive disease, extraarticular manifestations) and laboratory markers (eg, presence of rheumatoid factor and/or anticyclic citrullinated peptide antibody, inflammatory markers). Incident dementia, the outcome of interest, was ascertained through the use of International Classification of Disease, 9th … Address correspondence to Dr. S.E. Sattui, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, BST S273, 3500 Terrace Street, Pittsburgh, PA 15261, USA. Email: ssattui{at}pitt.edu. ER -