RT Journal Article SR Electronic T1 Does Age Matter in Psoriatic Arthritis? A Narrative Review JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1085 OP 1091 DO 10.3899/jrheum.210349 VO 49 IS 10 A1 George E. Fragoulis A1 Elena Nikiphorou A1 Iain B. McInnes A1 Stefan Siebert YR 2022 UL http://www.jrheum.org/content/49/10/1085.abstract AB Psoriatic arthritis (PsA) affects approximately 0.8% of the general population. PsA, together with psoriasis (PsO), constitute psoriatic disease (PsD). Comorbidities play an important role in the clinical expression and treatment of PsD. Aging adds another level of complexity, partly because age directly accrues increasing risk of comorbidities, but also because of its complex interactions with several factors such as depression and social determinants. Aging seems to have a “paradoxical association” with cardiovascular comorbidities, for which the relative risk is more pronounced in younger patients with PsD. It also affects treatment decisions and treatment response in patients with PsD. Finally, there is convincing evidence that there are clinical, genetic, and histopathological differences between early- and late-onset PsA and PsO. Herein, we review the effect of age in patients with PsD, with a focus on PsA, highlighting the need to consider this factor in routine clinical practice as well as in research.