RT Journal Article
SR Electronic
T1 Management of Calcinosis Cutis in Rheumatic Diseases
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 980
OP 989
DO 10.3899/jrheum.211393
VO 49
IS 9
A1 Hadiya Elahmar
A1 Brian M. Feldman
A1 Sindhu R. Johnson
YR 2022
UL http://www.jrheum.org/content/49/9/980.abstract
AB Calcinosis (hydroxyapatite and calcium phosphate crystal deposition) within the extracellular matrix of the dermis and subcutaneous tissue is a frequent manifestation of adult and pediatric systemic autoimmune rheumatic diseases, specifically systemic sclerosis, dermatomyositis, mixed connective tissue disease, and systemic lupus erythematosus. In this article, we review classification of calcinosis, highlight mechanisms that may contribute to the pathogenesis of calcinosis, and summarize the evidence evaluating nonpharmacologic and pharmacologic interventions for the treatment of calcinosis.