PT  - JOURNAL ARTICLE
AU  - Elahmar, Hadiya
AU  - Feldman, Brian M.
AU  - Johnson, Sindhu R.
TI  - Management of Calcinosis Cutis in Rheumatic Diseases
AID  - 10.3899/jrheum.211393
DP  - 2022 Sep 01
TA  - The Journal of Rheumatology
PG  - 980--989
VI  - 49
IP  - 9
4099  - http://www.jrheum.org/content/49/9/980.short
4100  - http://www.jrheum.org/content/49/9/980.full
SO  - J Rheumatol2022 Sep 01; 49
AB  - Calcinosis (hydroxyapatite and calcium phosphate crystal deposition) within the extracellular matrix of the dermis and subcutaneous tissue is a frequent manifestation of adult and pediatric systemic autoimmune rheumatic diseases, specifically systemic sclerosis, dermatomyositis, mixed connective tissue disease, and systemic lupus erythematosus. In this article, we review classification of calcinosis, highlight mechanisms that may contribute to the pathogenesis of calcinosis, and summarize the evidence evaluating nonpharmacologic and pharmacologic interventions for the treatment of calcinosis.