PT - JOURNAL ARTICLE AU - Jin Ding AU - Dangjie Wu AU - Qing Han AU - Kui Zhang AU - Zhaohui Zheng AU - Ping Zhu TI - Follow-up Contrast-Enhanced Ultrasonography of the Carotid Artery in Patients With Takayasu Arteritis: A Retrospective Study AID - 10.3899/jrheum.220114 DP - 2022 Jun 15 TA - The Journal of Rheumatology PG - jrheum.220114 4099 - http://www.jrheum.org/content/early/2022/08/09/jrheum.220114.short 4100 - http://www.jrheum.org/content/early/2022/08/09/jrheum.220114.full AB - Objective The literature describing follow-up carotid contrast-enhanced ultrasonography (CEUS) is limited. We report our experience with monitoring CEUS that is performed in patients with Takayasu arteritis (TAK). Methods We retrospectively analyzed patients with TAK who had undergone carotid CEUS 2 or more times with a follow-up duration of 12 or more months at Xijing Hospital between 2017 and 2020. We described how CEUS interpretation changed, and we recorded the state of remission (ie, bilateral CEUS visual grades ≤ 1) or relapse as determined by imaging. Results In total, 106 patients with TAK and 425 CEUS visits were included in the study; the median follow- up was 25 (IQR 18-30) months. The CEUS vascularization grade was significantly associated with the Kerr criteria (r = 0.532, P < 0.001), erythrocyte sedimentation rate (P < 0.001), and C-reactive protein level (P < 0.001). At baseline, 76 patients (71.7%) had active disease as determined by CEUS and 30 (28.3%) had inactive disease. The midterm assessment (median 13, IQR 10-16 months) showed that 29 out of 76 CEUS-active patients (38.2%) achieved complete response, 34 (44.7%) achieved partial response, and 13 (17.1%) did not respond. At the last visit, the total number of responders was 78 out of 94 (83.0%). CEUS relapse was observed in 28 out of 57 (49.1%) patients, with a median of 16 (IQR 10-21) months. The Kaplan-Meier curve demonstrated that the remission rate evaluated by the CEUS-combined method (median 22 months) was lower than that of the clinical-only evaluation (median 11 months; P < 0.001). Conclusion Response or relapse according to CEUS was detected in most patients during follow-up. CEUS is an effective technique for detecting carotid artery inflammation in patients with TAK.