PT - JOURNAL ARTICLE AU - Kawada, Tomoyuki TI - Febuxostat Use and Safety in Patients With Hyperuricemia AID - 10.3899/jrheum.220147 DP - 2022 Jun 15 TA - The Journal of Rheumatology PG - jrheum.220147 4099 - http://www.jrheum.org/content/early/2022/06/09/jrheum.220147.short 4100 - http://www.jrheum.org/content/early/2022/06/09/jrheum.220147.full AB - I read the paper by Deng et al,1 in which the authors conducted a metaanalysis to evaluate whether febuxostat use increased the risk of developing cardiovascular (CV) events, cardiac death, and all-cause mortality. The adjusted relative risk (RR) of febuxostat use for all-cause mortality was 0.87 (95% CI 0.57–1.32).