TY - JOUR T1 - Janus Kinase Inhibitors: Safety in Patients With Psoriatic Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 44 LP - 47 DO - 10.3899/jrheum.211329 VL - 49 IS - 6 Suppl 1 AU - Peter Nash Y1 - 2022/06/01 UR - http://www.jrheum.org/content/49/6_Suppl_1/44.abstract N2 - Janus kinase inhibitors (JAKi; or Jakinibs) have become widely prescribed around the world for a variety of immune-mediated inflammatory diseases, including psoriatic arthritis. A previous noninferiority surveillance study of patients aged > 50 years with rheumatoid arthritis and ≥ 1 additional cardiac risk factor raised a number of safety concerns. This review focuses on available safety data from peer-reviewed publications, as well as the most recent presentations from major conferences highlighting JAKi-associated adverse effects. The safety data for several types of JAKi are reviewed. The latest available safety data for tofacitinib, upadacitinib, filgotinib, deucravacitinib, and brepocitinib is presented. In addition, the findings from the oral surveillance study will be discussed to put safety concerns into context. ER -