RT Journal Article
SR Electronic
T1 Basic Science Session 2. Recent Advances in Our Understanding of Psoriatic Arthritis Pathogenesis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 16
OP 19
DO 10.3899/jrheum.211321
VO 49
IS 6 Suppl 1
A1 Erik Lubberts
A1 Jose U. Scher
A1 Oliver FitzGerald
YR 2022
UL http://www.jrheum.org/content/49/6_Suppl_1/16.abstract
AB The second basic science session at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting focused on 2 recent publications that have increased our understanding of the pathogenesis of psoriatic arthritis (PsA). Data from the first publication, presented by Prof. Erik Lubberts, showed that interleukin (IL)-17A is produced by CD4+ and not CD8+ T cells in PsA synovial fluid following T cell receptor activation. These findings contrast with previously published data, which had suggested that CD8+ T cells are a prominent source of IL-17A. In further experiments, they showed that when CD8+ T cells were stimulated with paramethoxyamphetamine/ionomycin, relatively high levels of IL-17A were detected. Prof. Jose Scher presented work on the role of the microbiome in PsA and more specifically, on pharmacomicrobiomics. He demonstrated the baseline collection of genomes and genes from the microbiota community (the metagenome) can be used as predictor for future treatment response in early rheumatoid arthritis and also likely in PsA.