PT  - JOURNAL ARTICLE
AU  - Nicki J.F.  Verweij
AU  - Jerney  de Jongh
AU  - Marieke M.  ter Wee
AU  - Gerben J.C.  Zwezerijnen
AU  - Maqsood Yaqub
AU  - Alexandre E.  Voskuyl
AU  - Adriaan A.  Lammertsma
AU  - Dirkjan  van Schaardenburg
AU  - Maarten Boers
AU  - Willem F.  Lems
AU  - Conny J. van der Laken
TI  - Whole body macrophage PET imaging for disease activity assessment in early rheumatoid arthritis
AID  - 10.3899/jrheum.210928
DP  - 2022 Apr 15
TA  - The Journal of Rheumatology
PG  - jrheum.210928
4099  - http://www.jrheum.org/content/early/2022/04/11/jrheum.210928.short
4100  - http://www.jrheum.org/content/early/2022/04/11/jrheum.210928.full
AB  - Objective To investigate the potential of whole body positron emission tomography/computed tomography (PET/CT) with a macrophage tracer to image arthritis in patients with early rheumatoid arthritis (RA). Methods Thirty-five previously untreated, clinically active early RA patients underwent whole body PET/CT scanning with the macrophage tracer (R)-[11C]PK11195 in addition to clinical assessment (Disease Activity Score of 44 joints [DAS44]). Tracer uptake was assessed quantitatively as standardized uptake values (SUV). In addition, two readers blinded to clinical assessment visually scored tracer uptake in joints. Clinical and PET variables were compared using Cohen's kappa, linear regression/correlation, and Ttests where appropriate. Results All but one patient showed enhanced tracer uptake in at least 1 joint. Twelve percent of all joints (171/1470) was visually PET positive, most frequently the small joints in feet (40%) and hands (37%), followed by wrists (15%). Correlations of visual scores with clinical findings both at patient and joint levels were absent or weak. In contrast, average SUV in hands, feet and whole body showed significant correlations with DAS- 44 scores, with the best correlation seen in the feet (R2 = 0.29, p < 0.01). Conclusion Clinically active, early RA patients had increased joint uptake of a macrophage PET tracer, especially in the feet. Quantitative, but not visual PET measures of whole body and joint groups, particularly the feet, showed moderate and statistically significant correlations with clinical outcome.