RT Journal Article SR Electronic T1 Characteristics, Comorbidities, and Outcomes of SARS-CoV-2 Infection in Patients With Autoimmune Conditions Treated With Systemic Therapies: A Population-based Study JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.210888 DO 10.3899/jrheum.210888 A1 Jeffrey R. Curtis A1 Xiaofeng Zhou A1 David T. Rubin A1 Walter Reinisch A1 Jinoos Yazdany A1 Philip C. Robinson A1 Yan Chen A1 Birgitta Benda A1 Ann Madsen A1 Jamie Geier YR 2021 UL http://www.jrheum.org/content/early/2021/12/12/jrheum.210888.abstract AB Objective To describe characteristics and coronavirus disease 2019 (COVID-19) clinical outcomes of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ulcerative colitis (UC) receiving systemic therapies vs the general population. Methods This descriptive retrospective cohort study used data from the United States Optum deidentified COVID-19 electronic health record dataset (2007–2020). Adults with COVID-19 were stratified into 3 disease cohorts (patients with RA, PsA, or UC who had received systemic therapy) and a comparator cohort not meeting these criteria. Incidence proportions of hospitalization and clinical manifestations of interest were calculated. Using logistic regression analyses, risk of endpoints was estimated, adjusting for demographics and demographics plus comorbidities. Results This analysis (February 1 to December 9, 2020) included 315,101 patients with COVID-19. Adjusting for demographics, COVID-19 patients with RA (n = 2306) had an increased risk of hospitalization (OR 1.54, 95% CI 1.39–1.70) and in-hospital death (OR 1.61, 95% CI 1.30–2.00) compared with the comparator cohort (n = 311,563). The increased risk was also observed when adjusted for demographics plus comorbidities (hospitalization OR 1.25, 95% CI 1.13–1.39 and in-hospital death OR 1.35, 95% CI 1.09–1.68]). The risk of hospitalization was lower in COVID-19 patients with RA receiving tumor necrosis factor inhibitors (TNFi) vs non-TNFi biologics (OR 0.32, 95% CI 0.20–0.53) and the comparator cohort (OR 0.77, 95% CI 0.51–1.17). The risk of hospitalization due to COVID-19 was similar between patients receiving tofacitinib and the comparator cohort. Conclusion Compared with the comparator cohort, patients with RA were at a higher risk of more severe or critical COVID-19 and, except for non-TNFi biologics, systemic therapies did not further increase the risk. (ENCePP; registration no. EU PAS 35384)