TY - JOUR T1 - Spectrum and Outcome of Noninfectious Aortitis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1583 LP - 1588 DO - 10.3899/jrheum.201274 VL - 48 IS - 10 AU - Yasmina Ferfar AU - Sarah Morinet AU - Olivier Espitia AU - Christian Agard AU - Mathieu Vautier AU - Cloé Comarmond AU - Anne Claire Desbois AU - Fanny Domont AU - Matthieu Resche-Rigon AU - Patrice Cacoub AU - Lucie Biard AU - David Saadoun Y1 - 2021/10/01 UR - http://www.jrheum.org/content/48/10/1583.abstract N2 - Objective To assess the spectrum and long-term outcome of patients with noninfectious aortitis.Methods We performed a retrospective multicenter study of 353 patients (median age at diagnosis was 62 [IQR 46–71] yrs and 242 [68.6%] patients were women) with noninfectious aortitis. Factors associated with vascular complications were assessed in multivariate analysis.Results We included 136 patients with giant cell arteritis (GCA), 96 with Takayasu arteritis (TA), 73 with clinically isolated aortitis (CIA), and 48 with aortitis secondary to inflammatory diseases (including Behçet disease, relapsing polychondritis, IgG4-related disease, Cogan syndrome, ankylosing spondylitis). After a median follow-up of 52 months, vascular complications were observed in 32.3%, revascularizations in 30% of patients, and death in 7.6%. The 5-year cumulative incidence of vascular complications was 58% (95% CI 41–71), 20% (95% CI 13–29), and 19% (95% CI 11–28) in CIA, GCA, and TA, respectively. In multivariate analysis, male sex (HR 2.10, 95% CI 1.45–3.05, P < 0.0001) and CIA (HR 1.76, 95% CI 1.11–2.81, P = 0.02) were independently associated with vascular complications.Conclusion Noninfectious aortitis accounts for significant morbidity and mortality. CIA seems to carry the highest rate of vascular complications. ER -