PT  - JOURNAL ARTICLE
AU  - Harvi F.  Hart
AU  - Tuhina Neogi
AU  - Michael LaValley
AU  - Daniel White
AU  - Yuqing Zhang
AU  - Michael C.  Nevitt
AU  - James Torner
AU  - Cora E.  Lewis
AU  - Joshua J.  Stefanik
TI  - Relationship of Patellofemoral Osteoarthritis to Changes in Performance-Based Physical Function Over 7 Years: The Multicenter Osteoarthritis Study
AID  - 10.3899/jrheum.210270
DP  - 2021 Sep 01
TA  - The Journal of Rheumatology
PG  - jrheum.210270
4099  - http://www.jrheum.org/content/early/2021/08/26/jrheum.210270.short
4100  - http://www.jrheum.org/content/early/2021/08/26/jrheum.210270.full
AB  - Objective Determine the relationship of patellofemoral osteoarthritis (OA) to changes in performancebased function over 7 years. Methods 2666 participants (62.2±8.0 years, BMI 30.6±5.9kg/m2; 60% female) from the Multicenter Osteoarthritis Study with knee radiographs at baseline and who completed repeated chair stands and 20- meter walk test at baseline, 2.5, 5, and 7 years were included. Generalized linear models assessed the relation of radiographic patellofemoral OA and radiographic patellofemoral OA with frequent knee pain to longitudinal changes in performance-based function. Analyses were adjusted for age, sex, BMI, tibiofemoral OA, and injury/surgery. Results Linear models demonstrated a significant group by time interaction for the repeated chair stands (p=0.04) and the 20-meter walk test (p<0.0001). Those with radiographic patellofemoral OA took 1.01seconds longer on the repeated chair stands (p=0.02) and 1.69seconds longer on the 20-meter walk test (p<0.0001) at 7 years compared with baseline. When examining the relation of radiographic patellofemoral OA with frequent knee pain to performance-based function there was a significant group by time interaction for repeated chair stands (p=0.05) and the 20-meter walk test (p<0.0001). Those with radiographic patellofemoral OA with frequent knee pain increased their time on the repeated chair stands by 1.12seconds (p=0.04) and 1.91seconds (p<0.0001) on the 20-meter walk test over 7 years. Conclusion Individuals with radiographic patellofemoral OA and those with radiographic patellofemoral OA with frequent knee pain have worsening of performance-based function over time. This knowledge may present opportunities to plan for early treatment strategies for patellofemoral OA to limit functional decline over time.