PT - JOURNAL ARTICLE AU - Sarah B. Lieber AU - Musarrat Nahid AU - Stephen Paget AU - Jessica R. Berman AU - Medha Barbhaiya AU - Lisa R. Sammaritano AU - Kyriakos Kirou AU - John A. Carrino AU - Mangala Rajan AU - Dina Sheira AU - Lisa A. Mandl TI - Evaluation of a Patient-Reported Frailty Tool in Women with Systemic Lupus Erythematosus AID - 10.3899/jrheum.201466 DP - 2021 Sep 01 TA - The Journal of Rheumatology PG - jrheum.201466 4099 - http://www.jrheum.org/content/early/2021/08/26/jrheum.201466.short 4100 - http://www.jrheum.org/content/early/2021/08/26/jrheum.201466.full AB - Objective Frailty is associated with mortality in systemic lupus erythematosus (SLE), but how best to measure frailty is unclear. We aimed to compare two frailty metrics, the self-reported FRAIL scale (FS) and the Fried phenotype (FP), in SLE to evaluate differences between frail and nonfrail women and whether frailty is associated with self-reported disability. Methods Adult women <70 years old with validated SLE and mild/moderate disease enrolled in this cross-sectional study between August 2018 and October 2019. Correlation and agreement between the FS and the FP were determined. Differences in sociodemographic and disease characteristics, patient-reported outcome measures (PROMs), and biomarkers between frail and non-frail participants were evaluated, as well as association of frailty with Valued Life Activities disability. Results Of 67 participants, 27% and 18% were frail according to the FS and the FP, respectively. Correlation (r=0.51; p<0.0001) and agreement (k=0.4627; p=0.0004) between the FS and the FP were significant. Frail women had greater disease damage, high-sensitivity C-reactive protein, and interleukin 6 and worse PROMs according to both frailty definitions. Both frailty measures were associated with self-reported disability after adjustment for age, comorbidity, and disease activity and damage; this relationship was attenuated for the FP. Conclusion Frailty prevalence was high in this cohort of women with SLE using both frailty definitions, suggesting that frailty may be accelerated in women with SLE, particularly when based exclusively on self-report. Frailty remained associated with self-reported disability in adjusted analyses. The FS may be an informative point-of-care tool to identify frail women with SLE.