TY - JOUR T1 - The Association of Psoriatic Arthritis with All-Cause Mortality and Leading Causes of Death in Psoriatic Arthritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.210159 SP - jrheum.210159 AU - Amir Haddad AU - Walid Saliba AU - Idit Lavi AU - Amin Batheesh AU - Samir Kasem AU - Tal Gazitt AU - Ilan Feldhamer AU - Arnon Dov Cohen AU - Devy Zisman Y1 - 2021/07/15 UR - http://www.jrheum.org/content/early/2021/07/11/jrheum.210159.abstract N2 - Objective To examine the association between PsA and all-cause mortality from a populationbased large database. Methods PsA Patients from the Clalit Health database were identified between 2003-2018 and matched to 4 controls by age, sex, ethnicity and index date. Patient's Demographics, comorbidities and treatments were extracted. Mortality data was obtained from the Notification of Death form. The proportionate mortality rate (PMR) of the leading causes of death was calculated and compared to the general population. Cox-proportional hazard regression models were used to estimate the crude and the multivariate adjusted hazard ratio (HR) for the association between PsA and all-cause mortality and for factors associated with mortality within the PsA group. Results 5275 PsA patients and 21,011 controls were included and followed for 7.2±4.4 years. The mean age was 51.7±15.4 years, and 53% were females. 38.2% of PsA patients were on biologics. 471(8.9%) patients died in the PsA group compared to 1,668(7.9%) in the control group. The crude HR for the association of PsA and allcause mortality was 1.16 (95%CI 1.042-1.29) and 1.02 (95%CI 0.90-1.15) on multivariate analysis. Malignancy was the leading cause of death (26%), followed by ischemic heart disease (15.8%) in keeping with the order in the general population. Older age, male sex, lower socioeconomic status, increased body mass index, Charlson comorbidity index scores and history psoriasis or hospitalization during 1- year prior to entry were positive predictors for mortality. Conclusion No clinically relevant increase in mortality rate was observed in PsA patients, specific PMRs were similar to the general population. ER -