RT Journal Article
SR Electronic
T1 Smoking and Methotrexate Inefficacy in Rheumatoid Arthritis: What About Underlying Molecular Mechanisms?
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.210217
DO 10.3899/jrheum.210217
A1 Gerrit Jansen
A1 Maurits C.F.J.  de Rotte
A1 Robert  de Jonge
YR 2021
UL http://www.jrheum.org/content/early/2021/06/10/jrheum.210217.abstract
AB The study by Safy-Khan, et al in the current issue of The Journal of Rheumatology1 reports that in a methotrexate (MTX)-based treatment regimen for patients with early arthritis, current smoking was significantly associated with a smaller reduction of Disease Activity Score in 28 joints (DAS28) over time compared to noncurrent smoking. This negative effect of current smoking on DAS28 was dose-dependent: patients who smoked 10–19 cigarettes per day did worse than patients who smoked 1–9 cigarettes per day.