RT Journal Article
SR Electronic
T1 Risk of Severe COVID-19 Infection in Patients With Inflammatory Rheumatic Diseases
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1098
OP 1102
DO 10.3899/jrheum.200755
VO 48
IS 7
A1 Javier Bachiller-Corral
A1 Alina Boteanu
A1 Maria Jesus Garcia-Villanueva
A1 Carlos de la Puente
A1 Marcelino Revenga
A1 M. Consuelo Diaz-Miguel
A1 Ana Rodriguez-Garcia
A1 Jose Luis Morell-Hita
A1 Marta Valero
A1 Carmen Larena
A1 Maria Blazquez-Cañamero
A1 Carlos A. Guillen-Astete
A1 Sandra Garrote
A1 Cristina Sobrino
A1 Carmen Medina-Quiñones
A1 Mónica Vazquez-Diaz
YR 2021
UL http://www.jrheum.org/content/48/7/1098.abstract
AB Objective. To describe the cohort of patients with inflammatory rheumatic diseases (IRD) hospitalized due to SARS-CoV-2 infection in the Ramón y Cajal Hospital, and to determine the increased risk of severe coronavirus disease 2019 (COVID-19) in patients with no IRD.Methods. This is a retrospective single-center observational study of patients with IRD actively monitored in the Department of Rheumatology who were hospitalized due to COVID-19.Results. Forty-one (1.8%) out of 2315 patients admitted due to severe SARS-CoV-2 pneumonia suffered from an IRD. The admission OR for patients with IRD was 1.91 against the general population, and it was considerably higher in patients with Sjögren syndrome, vasculitis, and systemic lupus erythematosus. Twenty-seven patients were receiving treatment for IRD with corticosteroids, 23 with conventional DMARDs, 12 with biologics (7 rituximab [RTX], 4 anti–tumor necrosis factor [anti-TNF], and 1 abatacept), and 1 with Janus kinase inhibitors. Ten deaths were registered among patients with IRD. A higher hospitalization rate and a higher number of deaths were observed in patients treated with RTX (OR 12.9) but not in patients treated with anti-TNF (OR 0.9).Conclusion. Patients with IRD, especially autoimmune diseases and patients treated with RTX, may be at higher risk of severe pneumonia due to SARS-CoV-2 compared to the general population. More studies are needed to analyze this association further in order to help manage these patients during the pandemic.