RT Journal Article
SR Electronic
T1 Absence of Association Between Abatacept Exposure and Initial Infection in Patients With Juvenile Idiopathic Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1073
OP 1081
DO 10.3899/jrheum.200154
VO 48
IS 7
A1 Nicolino Ruperto
A1 Hermine I. Brunner
A1 Nikolay Tzaribachev
A1 Gabriel Vega-Cornejo
A1 Ingrid Louw
A1 Rolando Cimaz
A1 Jason Dare
A1 Graciela Espada
A1 Enrique Faugier
A1 Manuel Ferrandiz
A1 Valeria Gerloni
A1 Pierre Quartier
A1 Clovis Artur Silva
A1 Linda Wagner-Weiner
A1 Yash Gandhi
A1 Julie Passarell
A1 Marleen Nys
A1 Robert Wong
A1 Alberto Martini
A1 Daniel J. Lovell
YR 2021
UL http://www.jrheum.org/content/48/7/1073.abstract
AB Objective. To assess the relationship between infection risk and abatacept (ABA) exposure levels in patients with polyarticular-course juvenile idiopathic arthritis (pJIA) following treatment with subcutaneous (SC) and intravenous (IV) ABA.Methods. Data from 2 published studies (ClinicalTrials.gov: NCT01844518, NCT00095173) of ABA treatment in pediatric patients were analyzed. One study treated patients aged 2–17 years with SC ABA and the other treated patients aged 6–17 years with IV ABA. Association between serum ABA exposure measures and infection was evaluated using Kaplan-Meier plots of probability of first infection vs time on treatment by ABA exposure quartiles and log-rank tests. Number of infections by ABA exposure quartiles was investigated.Results. Overall, 343 patients were included in this analysis: 219 patients received SC ABA and 124 patients received IV ABA. Overall, 237/343 (69.1%) patients had ≥ 1 infection over 24 months. No significant difference in time to first infection across 4 quartiles of ABA exposure levels was observed in the pooled (P = 0.45), SC (2–5 yrs: P = 0.93; 6–17 yrs: P = 0.48), or IV (P = 0.50) analyses. Concomitant use of methotrexate and glucocorticoids (at baseline and throughout) with ABA did not increase infection risk across the ABA exposure quartiles. There was no evidence of association between number of infections and ABA exposure quartiles. No opportunistic infections related to ABA were reported.Conclusion. In patients aged 2–17 years with pJIA, no evidence of association between higher levels of exposure to IV ABA or SC ABA and incidence of infection was observed.