RT Journal Article
SR Electronic
T1 Ethnicity and Neonatal Lupus Erythematosus Manifestations Risk in a Large Multiethnic Cohort
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.201338
DO 10.3899/jrheum.201338
A1 Talia Diaz
A1 Daniela Dominguez
A1 Edgar Jaeggi
A1 Andrea M.  Knight
A1 Carl A.  Laskin
A1 Lawrence Ng
A1 Franklin Silverio
A1 Earl D.  Silverman
A1 Linda T.  Hiraki
YR 2021
UL http://www.jrheum.org/content/early/2021/05/27/jrheum.201338.abstract
AB Objective To evaluate the association between ethnicity and neonatal lupus erythematosus (NLE), as well as specific NLE manifestations in a large multiethnic population. Methods We conducted a cohort study of the children (≤ 1 yr of age) seen in the NLE clinic at The Hospital for Sick Children (SickKids), between January 2011 and April 2019. The cohort was divided into European, non-European, and mixed European–non-European groups according to parent-reported child's ethnicity (Canada Census categories). Outcomes were NLE and specific NLE manifestations (cardiac, cutaneous, cytopenias, transaminitis, and macrocephaly). The frequency of NLE and specific manifestations were compared between ethnic groups (Fisher exact test). We tested the association between ethnicity and (1) NLE risk, and (2) specific NLE manifestations with logistic regression models, including covariates for child's sex, maternal rheumatic disease status during pregnancy, and maternal use of antimalarials during pregnancy (multiple comparisons threshold P < 0.008). Results We included 324 children born to 270 anti-Ro antibody–positive mothers. Median age at first visit was 1.8 (IQR 1.4–2.3) months, and median follow-up time was 12 (IQR 2–24) months. The majority was non-European (48%), with 34% European, and 18% mixed European–non-European. There was no significant association between non-European ethnicity (OR 1.18, 95% CI 0.71–1.94, P = 0.51), mixed European–non-European ethnicity (OR 1.13, 95% CI 0.59–2.16, P = 0.70), and NLE risk compared with European ethnicity. We also did not find an association between ethnicity and specific NLE manifestations in univariate or multivariable-adjusted models. Conclusion In a large multiethnic cohort, there was no association between a child's ethnicity and NLE risk or specific NLE manifestations.