RT Journal Article
SR Electronic
T1 Pustular Psoriasis and Associated Musculoskeletal Disorders
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 34
OP 38
DO 10.3899/jrheum.201673
VO 97
A1 Kristina Callis Duffin
A1 Hervé Bachelez
A1 Philip J. Mease
A1 Cheryl Rosen
A1 Amit Garg
A1 Eric Zudak
A1 Ori Elkayam
A1 Joseph F. Merola
A1 Jeffrey Chau
A1 Mitsumasa Kishimoto
A1 Victoria Furer
A1 Philip S. Helliwell
YR 2021
UL http://www.jrheum.org/content/97/34.abstract
AB Pustular psoriasis (PsO) is an uncommon variant of PsO that may present in a generalized or localized fashion with or without musculoskeletal or systemic inflammatory involvement.Generalized pustular PsO (GPP) presents as a widespread acute or subacute pustular eruption that may be familial and is often associated with severe flares and systemic inflammation. The palmoplantar pustulosis variant is localized to palms and soles, whereas acrodermatitis continua of Hallopeau is localized to the nail apparatus. Patients with pustular PsO may have overlapping plaque PsO and may develop psoriatic arthritis (PsA). Pustulosis is also a feature of both synovitis, acne, pustulosis, hyperostosis, osteomyelitis (SAPHO) syndrome and chronic non-bacterial osteomyelitis. At the 2020 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting, members were given an overview of the cutaneous features of pustular PsO, SAPHO, and recent insights into the genetics of GPP, leading to new targeted drug therapies and the development of validated endpoints.