RT Journal Article
SR Electronic
T1 Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 760
OP 766
DO 10.3899/jrheum.200391
VO 48
IS 5
A1 Elham Rezaei
A1 Marianna M. Newkirk
A1 Zhenhong Li
A1 John R. Gordon
A1 Kiem G. Oen
A1 Susanne M. Benseler
A1 Gilles Boire
A1 David A. Cabral
A1 Sarah Campillo
A1 Gaëlle Chédeville
A1 Anne-Laure Chetaille
A1 Paul Dancey
A1 Ciaran Duffy
A1 Karen Watanabe Duffy
A1 Kristin Houghton
A1 Adam M. Huber
A1 Roman Jurencak
A1 Bianca Lang
A1 Kimberly A. Morishita
A1 Ross E. Petty
A1 Suzanne E. Ramsey
A1 Johannes Roth
A1 Rayfel Schneider
A1 Rosie Scuccimarri
A1 Lynn Spiegel
A1 Elizabeth Stringer
A1 Shirley M.L. Tse
A1 Lori B. Tucker
A1 Stuart E. Turvey
A1 Rae S.M. Yeung
A1 Alan M. Rosenberg
A1 Alan M. Rosenberg for the BBOP Study Group
YR 2021
UL http://www.jrheum.org/content/48/5/760.abstract
AB Objectives This study aimed to expand knowledge about soluble low-density lipoprotein receptor-related protein 1 (sLRP1) in juvenile idiopathic arthritis (JIA) by determining associations of sLRP1 levels in nonsystemic JIA patients with clinical and inflammatory biomarker indicators of disease activity.Methods Plasma sLRP1 and 44 inflammation-related biomarkers were measured at enrollment and 6 months later in a cohort of 96 newly diagnosed Canadian patients with nonsystemic JIA. Relationships between sLRP1 levels and indicators of disease activity and biomarker levels were analyzed at both visits.Results At enrollment, sLRP1 levels correlated negatively with age and active joint counts. Children showed significantly higher levels of sLRP1 than adolescents (mean ranks: 55.4 and 41.9, respectively; P = 0.02). Participants with 4 or fewer active joints, compared to those with 5 or more active joints, had significantly higher sLRP1 levels (mean ranks: 56.2 and 40.7, respectively; P = 0.006). At enrollment, considering the entire cohort, sLRP1 correlated negatively with the number of active joints (r = –0.235, P = 0.017). In the entire cohort, sLRP1 levels at enrollment and 6 months later correlated with 13 and 6 pro- and antiinflammatory biomarkers, respectively. In JIA categories, sLRP1 correlations with inflammatory markers were significant in rheumatoid factor–negative polyarticular JIA, oligoarticular JIA, enthesitis-related arthritis, and psoriatic arthritis at enrollment. Higher sLRP1 levels at enrollment increased the likelihood of absence of active joints 6 months later.Conclusion Plasma sLRP1 levels correlate with clinical and biomarker indicators of short-term improvement in JIA disease activity, supporting sLRP1 as an upstream biomarker of potential utility for assessing JIA disease activity and outcome prediction.