@article {Diazjrheum.201338, author = {Talia Diaz and Daniela Dominguez and Edgar Jaeggi and Andrea Knight and Carl A. Laskin and Lawrence Ng and Franklin Silverio and Earl D. Silverman and Linda T. Hiraki}, title = {Ethnicity and Neonatal Lupus Erythematosus Manifestations Risk in a Large Multi-Ethnic Cohort}, elocation-id = {jrheum.201338}, year = {2021}, doi = {10.3899/jrheum.201338}, publisher = {The Journal of Rheumatology}, abstract = {Objective To evaluate the association between ethnicity and neonatal lupus erythematosus (NLE), as well as specific NLE manifestations in a large multi-ethnic population. Methods We conducted a cohort study of the children (<=1 year of age) seen in the NLE clinic at SickKids, between January 2011 and April 2019. The cohort was divided into European, non-European and Mixed European{\textendash}Non-European groups according to parent reported child{\textquoteright}s ethnicity (Canada census categories). Outcomes were NLE and specific NLE manifestations (cardiac, cutaneous, cytopenias, transaminitis and macrocephaly). The frequency of NLE and specific manifestations were compared between ethnic groups (Fisher{\textquoteright}s exact test). We tested the association between ethnicity and 1) NLE risk and 2) specific NLE manifestations with logistic regression models, including covariates for child{\textquoteright}s sex, maternal rheumatic disease status during pregnancy, and maternal use of antimalarials during pregnancy (multiple comparisons threshold p-value\<0.008). Results We included 324 children born to 270 anti-Ro antibody positive mothers. Median age at first visit: 1.8 months (IQR: 1.4, 2.3 months). Median follow-up time: 12 months (IQR: 2,24months). The majority were non-European (48\%), with 34\% European, and 18\% Mixed European{\textendash}Non-European. There was no significant association between non-European ethnicity (OR 1.14, 95\% CI:0.69-1.89, p=0.59), Mixed European-Non-European ethnicity (OR 1.06, 95\% CI:0.55-2.06, p=0.84) and NLE risk compared with European ethnicity. We also did not find an association between ethnicity and specific NLE manifestations, in univariate or multivariable adjusted models. Conclusion In a large multiethnic cohort, there was no association between child{\textquoteright}s ethnicity and NLE risk, nor specific NLE manifestations.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2021/03/24/jrheum.201338}, eprint = {https://www.jrheum.org/content/early/2021/03/24/jrheum.201338.full.pdf}, journal = {The Journal of Rheumatology} }