TY - JOUR T1 - Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.200391 SP - jrheum.200391 AU - Elham Rezaei AU - Marianna M. Newkirk AU - Zhenhong Li AU - John R. Gordon AU - Kiem G. Oen AU - Susanne M. Benseler AU - Gilles Boire AU - David A. Cabral AU - Sarah Campillo AU - Gaëlle Chédeville AU - Anne-Laure Chetaille AU - Paul Dancey AU - Ciaran Duffy AU - Karen Watanabe Duffy AU - Kristin Houghton AU - Adam M. Huber AU - Roman Jurencak AU - Bianca Lang AU - Kimberly A. Morishita AU - Ross E. Petty AU - Suzanne E. Ramsey AU - Johannes Roth AU - Rayfel Schneider AU - Rosie Scuccimarri AU - Lynn Spiegel AU - Elizabeth Stringer AU - Shirley M.L. Tse AU - Lori B. Tucker AU - Stuart E. Turvey AU - Rae S.M. Yeung AU - Alan M. Rosenberg Y1 - 2020/10/15 UR - http://www.jrheum.org/content/early/2021/02/10/jrheum.200391.abstract N2 - Objective This study aimed to expand knowledge about soluble low-density lipoprotein receptor-related protein 1 (sLRP1) in juvenile idiopathic arthritis ( JIA) by determining associations of sLRP1 levels in nonsystemic JIA patients with clinical and inflammatory biomarker indicators of disease activity. Methods Plasma sLRP1 and 44 inflammation-related biomarkers were measured at enrollment and 6 months later in a cohort of 96 newly diagnosed Canadian patients with nonsystemic JIA. Relationships between sLRP1 levels and indicators of disease activity and biomarker levels were analyzed at both visits. Results At enrollment, sLRP1 levels correlated negatively with age and active joint counts. Children showed significantly higher levels of sLRP1 than adolescents (mean ranks: 55.4 and 41.9, respectively; P = 0.02). Participants with 4 or fewer active joints, compared to those with 5 or more active joints, had significantly higher sLRP1 levels (mean ranks: 56.2 and 40.7, respectively; P = 0.006). At enrollment, considering the entire cohort, sLRP1 correlated negatively with the number of active joints (r = –0.235, P = 0.017). In the entire cohort, sLRP1 levels at enrollment and 6 months later correlated with 13 and 6 pro- and antiinflammatory biomarkers, respectively. In JIA categories, sLRP1 correlations with inflammatory markers were significant in rheumatoid factor–negative polyarticular JIA, oligoarticular JIA, enthesitis-related arthritis, and psoriatic arthritis at enrollment. Higher sLRP1 levels at enrollment increased the likelihood of absence of active joints 6 months later. Conclusion Plasma sLRP1 levels correlate with clinical and biomarker indicators of short-term improvement in JIA disease activity, supporting sLRP1 as an upstream biomarker of potential utility for assessing JIA disease activity and outcome prediction. ER -