RT Journal Article
SR Electronic
T1 Correlation of a Modified Disease Activity Score (DAS) with the Validated Original DAS in Patients with Juvenile Dermatomyositis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 101
OP 104
DO 10.3899/jrheum.191255
VO 48
IS 1
A1 Hayyah Clairman
A1 Saunya Dover
A1 Kristi Whitney
A1 Jo-Anne Marcuz
A1 Audrey Bell-Peter
A1 Brian M. Feldman
YR 2021
UL http://www.jrheum.org/content/48/1/101.abstract
AB Objective. Juvenile dermatomyositis (JDM) is a rare disease in children that is treatable, but patients may suffer from long-term effects. Clinical trials are needed to find better treatments for affected patients. Among validated tools for evaluating disease activity clinically is the Disease Activity Score (DAS), but it is not routinely collected in all clinics. We developed a modified DAS (DASmod), which can be scored using data routinely collected by our clinical staff and has been used in previous studies. The aim of this study was to determine if our DASmod correlates with the validated DAS in patients with JDM.Methods. In this study, we used DASmod (scored 0–12) and DAS (scored 0–20) scores for patients with JDM in our clinic. We analyzed the correlation between the DASmod and the validated DAS.Results. For 51 patients seen in our JDM clinic, the median (IQR) DASmod score was 2.0 (0–4.0) and the DAS score was 3.0 (0–5.5). Scores on the 2 tools were highly positively correlated (r = 0.94, P < 0.001, 95% CI 0.89–0.96). The linear regression was significant [R2 = 0.88, F (1, 49) = 357.60, P < 0.001] and in this dataset, the tools can be used interchangeably with the regression equation: DAS score = –0.26 + 1.5*DASmod.Conclusion. If the regression equation from this dataset is successfully tested against future datasets, then further research collaborations between centers that collect different data related to disease activity in children with JDM will be facilitated.