TY - JOUR T1 - Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.200054 SP - jrheum.200054 AU - Guangju Zhai AU - Xianbang Sun AU - Edward W. Randell AU - Ming Liu AU - Na Wang AU - Irina Tolstykh AU - Proton Rahman AU - James Torner AU - Cora E. Lewis AU - Michael C. Nevitt AU - Ali Guermazi AU - Frank Roemer AU - David T. Felson Y1 - 2020/05/01 UR - http://www.jrheum.org/content/early/2020/11/10/jrheum.200054.abstract N2 - Objective To identify plasma markers associated with an increased risk of radiographic knee osteoarthritis (OA) progression using a metabolomics approach. Methods Study participants were from the Multicenter Osteoarthritis Study (MOST) and were categorized into 2 groups based on the presence of baseline radiographic OA. Subjects in group 1 had unilateral knee OA and subjects in group 2 had bilateral knee OA. Progression was defined as a half-grade or greater worsening in joint space width at 30-month follow-up. For group 1, a participant progressed when their OA knee showed radiographic progression and the contralateral knee developed OA; for group 2, a participant progressed when both knees with OA showed radiographic progression. Metabolomic profiling was performed on plasma samples collected at baseline and logistic regression was performed to test the association between each metabolite and knee OA progression after adjustment for age, sex, BMI, and clinic site. Significance was defined as P ≤ 0.0003 in the combined analysis. Results There were 234 progressors (57 in group 1 and 177 in group 2) and 322 nonprogressors (206 in group 1 and 116 in group 2) included in the analyses. Among 157 metabolites studied, we found that odds of progression were 1.46 times higher per SD increase of phenylalanine level (95% CI 1.20–1.77, P = 0.0001) in the combined analysis. Sex-specific analysis showed that an association was seen in women (P = 0.0002) but not in men. Conclusion Our data suggest that phenylalanine might be a novel plasma marker for higher risk of bilateral radiographic knee OA progression in women. ER -