PT  - JOURNAL ARTICLE
AU  - Adam S.  Faye
AU  - Kate E.  Lee
AU  - Monika Laszkowska
AU  - Judith Kim
AU  - John William  Blackett
AU  - Anna S.  McKenney
AU  - Anna Krigel
AU  - Jon T.  Giles
AU  - Runsheng Wang
AU  - Elana J.  Bernstein
AU  - Peter H.R.  Green
AU  - Suneeta Krishnareddy
AU  - Chin Hur
AU  - Benjamin Lebwohl
TI  - Risk of Adverse Outcomes in Hospitalized Patients with Autoimmune Disease and COVID-19: A Matched Cohort Study from New York City
AID  - 10.3899/jrheum.200989
DP  - 2020 Nov 01
TA  - The Journal of Rheumatology
PG  - jrheum.200989
4099  - http://www.jrheum.org/content/early/2020/11/06/jrheum.200989.short
4100  - http://www.jrheum.org/content/early/2020/11/06/jrheum.200989.full
AB  - Objective To examine the impact of autoimmune disease on the composite outcome of intensive care unit admission, intubation, or death, from COVID-19 in hospitalized patients. Methods Retrospective cohort study of 186 patients hospitalized with COVID-19 between March 1st–April 15th, 2020 at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. The cohort included 62 patients with autoimmune disease and 124 age- and sex-matched controls. The primary outcome was a composite of intensive care unit admission, intubation, and death, with secondary outcome assessing time to in-hospital death. Baseline demographics, comorbidities, medications, vital signs, and laboratory values were collected. Conditional logistic regression and Cox proportional hazards regression were used to assess the association between autoimmune disease and clinical outcomes. Results Patients with autoimmune disease were more likely to have at least one comorbidity (25.8% vs. 12.9%, p=0.03), take chronic immunosuppressive medications (66.1% vs. 4.0%, p<0.01), and have had a solid organ transplant (16.1% vs. 1.6%, p<0.01). There were no significant differences in intensive care unit admission (14.2% vs. 19.4%, p=0.44), intubation (14.2% vs. 17.7%, p=0.62) or death (17.5% vs. 14.5%, p=0.77). On multivariable analysis, patients with autoimmune disease were not at an increased risk for a composite outcome of intensive care unit admission, intubation, or death (adjOR 0.79, 95%CI 0.37-1.67). On Cox regression, autoimmune disease was not associated with in-hospital mortality (adjHR 0.73, 95%CI 0.33-1.63). Conclusion Among patients hospitalized with COVID-19, individuals with autoimmune disease did not have an increased risk of a composite outcome of intensive care unit admission, intubation, or death.