@article {Fayejrheum.200989, author = {Adam S. Faye and Kate E. Lee and Monika Laszkowska and Judith Kim and John William Blackett and Anna S. McKenney and Anna Krigel and Jon T. Giles and Runsheng Wang and Elana J. Bernstein and Peter H.R. Green and Suneeta Krishnareddy and Chin Hur and Benjamin Lebwohl}, title = {Risk of Adverse Outcomes in Hospitalized Patients with Autoimmune Disease and COVID-19: A Matched Cohort Study from New York City}, elocation-id = {jrheum.200989}, year = {2020}, doi = {10.3899/jrheum.200989}, publisher = {The Journal of Rheumatology}, abstract = {Objective To examine the impact of autoimmune disease on the composite outcome of intensive care unit admission, intubation, or death, from COVID-19 in hospitalized patients. Methods Retrospective cohort study of 186 patients hospitalized with COVID-19 between March 1st{\textendash}April 15th, 2020 at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. The cohort included 62 patients with autoimmune disease and 124 age- and sex-matched controls. The primary outcome was a composite of intensive care unit admission, intubation, and death, with secondary outcome assessing time to in-hospital death. Baseline demographics, comorbidities, medications, vital signs, and laboratory values were collected. Conditional logistic regression and Cox proportional hazards regression were used to assess the association between autoimmune disease and clinical outcomes. Results Patients with autoimmune disease were more likely to have at least one comorbidity (25.8\% vs. 12.9\%, p=0.03), take chronic immunosuppressive medications (66.1\% vs. 4.0\%, p\<0.01), and have had a solid organ transplant (16.1\% vs. 1.6\%, p\<0.01). There were no significant differences in intensive care unit admission (14.2\% vs. 19.4\%, p=0.44), intubation (14.2\% vs. 17.7\%, p=0.62) or death (17.5\% vs. 14.5\%, p=0.77). On multivariable analysis, patients with autoimmune disease were not at an increased risk for a composite outcome of intensive care unit admission, intubation, or death (adjOR 0.79, 95\%CI 0.37-1.67). On Cox regression, autoimmune disease was not associated with in-hospital mortality (adjHR 0.73, 95\%CI 0.33-1.63). Conclusion Among patients hospitalized with COVID-19, individuals with autoimmune disease did not have an increased risk of a composite outcome of intensive care unit admission, intubation, or death.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2020/11/06/jrheum.200989}, eprint = {https://www.jrheum.org/content/early/2020/11/06/jrheum.200989.full.pdf}, journal = {The Journal of Rheumatology} }