TY - JOUR T1 - Upfront Combination Therapy With Rituximab and Mycophenolate Mofetil for Progressive Systemic Sclerosis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.200484 SP - jrheum.200484 AU - Doron Rimar AU - Itzhak Rosner AU - Gleb Slobodin Y1 - 2020/10/15 UR - http://www.jrheum.org/content/early/2020/10/13/jrheum.200484.abstract N2 - Systemic sclerosis (SSc) is a complex disease involving multiple pathophysiological pathways: autoimmunity, vasculopathy, and fibrosis, all of which are interrelated. Most of the damage consists of skin and lung fibrosis, and is accumulated within the first 2 years of disease in rapidly progressive patients with a serology of anti-SCL-70 or antiā€“RNA polymerase III (RNAP3)1. ER -