RT Journal Article
SR Electronic
T1 Lupus Low Disease Activity State achievement is important for reducing adverse outcomes in pregnant patients with systemic lupus erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.200802
DO 10.3899/jrheum.200802
A1 Ji-Won Kim
A1 Ju-Yang Jung
A1 Hyoun-Ah Kim
A1 Jeong In  Yang
A1 Dong Wook  Kwak
A1 Chang-Hee Suh
YR 2020
UL http://www.jrheum.org/content/early/2020/10/13/jrheum.200802.abstract
AB Objective This study aimed to examine the frequency and risk factors of complications during pregnancy in women with systemic lupus erythematosus (SLE). Methods The medical records of patients with SLE and age-matched controls at Ajou University Hospital were collected. Clinical features and pregnancy complications in women with SLE were compared to those in controls. Multivariate logistic regression analysis was performed to determine the predictors of adverse maternal and fetal outcomes. Results We analyzed 163 pregnancies in patients with SLE and 596 pregnancies in the general population; no significant differences regarding demographic characteristics were noted. Lupus patients experienced a higher rate of stillbirth (odds ratio [OR], 13.2), pre-eclampsia (OR, 4.3), preterm labor (OR, 2.6), intrauterine growth retardation (OR, 2.5), admission to neonatal intensive care unit (OR, 2.2) and emergency cesarean section (OR, 1.9) than control group. Multivariate regression analysis revealed that thrombocytopenia, low complement, high proteinuria, high SLE Disease Activity Index (SLEDAI), low Lupus Low Disease Activity State (LLDAS) achievement rate, and high corticosteroid dose were associated with adverse pregnancy outcomes. In the receiver operating characteristic curve analysis, the optimal cut-off value for the cumulative and mean corticosteroid doses were 3,500 mg and 6 mg, respectively. Conclusion Pregnant women with SLE have a higher risk of adverse pregnancy outcomes. Pregnancies are recommended to be delayed until achieving LLDAS and should be closely monitored with the lowest possible dose of corticosteroids.