TY - JOUR T1 - Near Tetraploidy in a Patient with Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol SP - 1725 LP - 1726 DO - 10.3899/jrheum.191409 VL - 47 IS - 11 AU - Biyu Zhang AU - Huihui Chi AU - Yutong Su Y1 - 2020/11/01 UR - http://www.jrheum.org/content/47/11/1725.abstract N2 - Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that predominantly affects females1. As for the higher susceptibility to SLE for women, different hypotheses were proposed to explain this phenomenon, including sex hormones2 and the dose effect of X chromosome number3. Some congenital sex chromosome abnormalities, such as Klinefelter syndrome (47, XXY karyotype) and trisomy X (47, XXX karyotype), have received much attention, for the reason that people with X chromosome polysomy may be at an increased risk of developing some autoimmune diseases including SLE. However, SLE patients with polyploidy or near polyploidy, a condition in which a cell has more than 2 sets of chromosomes, were not reported previously. Here we present a patient whose chromosomal analysis showed near tetraploidy in a bone marrow (BM) specimen.Ethics approval was obtained for this case report from the Ethics Committee of Ruijin Hospital (ethics committee approval no. 235). Because all the medical data were acquired from the previous diagnosis and treatment procedures of the patient, and no personal identity information was revealed in this case report, the ethics board granted a waiver of written informed consent.A … Address correspondence to Dr. Y. Su, Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Shanghai 200025, China. Email: suyt2015{at}163.com. ER -