PT - JOURNAL ARTICLE AU - Mendel, Arielle AU - Ennis, Daniel AU - Go, Ellen AU - Bakowsky, Volodko AU - Baldwin, Corisande AU - Benseler, Susanne M. AU - Cabral, David A. AU - Carette, Simon AU - Clements-Baker, Marie AU - Clifford, Alison AU - Cohen Tervaert, Jan Willem AU - Cox, Gerard AU - Dehghan, Natasha AU - Dipchand, Christine AU - Dhindsa, Navjot AU - Famorca, Leilani AU - Fifi-Mah, Aurore AU - Garner, Stephanie AU - Girard, Louis-Philippe AU - Lessard, Clode AU - Liang, Patrick AU - Noone, Damien AU - Makhzoum, Jean-Paul AU - Milman, Nataliya AU - Pineau, Christian A. AU - Reich, Heather N. AU - Rhéaume, Maxime AU - Robinson, David B. AU - Rumsey, Dax G. AU - Towheed, Tanveer E. AU - Trudeau, Judith AU - Twilt, Marinka AU - Yacyshyn, Elaine AU - Yeung, Rae AU - Barra, Lillian AU - Khalidi, Nader AU - Pagnoux, Christian TI - CanVasc consensus recommendations for the management of antineutrophil cytoplasm antibody-associated vasculitis: 2020 update AID - 10.3899/jrheum.200721 DP - 2020 Sep 15 TA - The Journal of Rheumatology PG - jrheum.200721 4099 - http://www.jrheum.org/content/early/2020/09/10/jrheum.200721.short 4100 - http://www.jrheum.org/content/early/2020/09/10/jrheum.200721.full AB - Objective In 2015, the Canadian Vasculitis Research Network (CanVasc) created recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada. The current update aimed to revise existing recommendations and create additional recommendations, as needed, based on a review of new available evidence. Methods A needs assessment survey of CanVasc members informed questions for an updated systematic literature review (publications spanning May 2014-September 2019) using Medline, Embase, and Cochrane. New and revised recommendations were developed and categorized according to the level of evidence and strength of each recommendation. The CanVasc working group used a two-step modified Delphi procedure to reach >80% consensus on the inclusion, wording and grading of each new and revised recommendation. Results Eleven new and 16 revised recommendations were created, and 12 original (2015) recommendations were retained. New and revised recommendations are discussed in detail within this document. Five original recommendations were removed, of which 4 were incorporated into the explanatory text. The supplementary appendix for practical use was revised to reflect the updated recommendations. Conclusion The 2020 updated recommendations provide rheumatologists, nephrologists, and other specialists caring for patients with AAV in Canada with new management guidance, based on current evidence and consensus from Canadian experts.