TY - JOUR T1 - Antineoplastic Drug-induced Aortitis: An Unraveled Adverse Effect Using the World Health Organization Pharmacovigilance Database JF - The Journal of Rheumatology JO - J Rheumatol SP - 1298 LP - 1300 DO - 10.3899/jrheum.200023 VL - 47 IS - 8 AU - CAMILLE METTLER AU - LAURENT CHOUCHANA AU - BENJAMIN TERRIER Y1 - 2020/08/01 UR - http://www.jrheum.org/content/47/8/1298.abstract N2 - To the Editor:Aortitis is a rare inflammatory disease ranging from asymptomatic aortic thickening to life-threatening manifestations, especially aortic dissection or stenosis. Aortitis mainly occurs during systemic inflammatory diseases (giant cell arteritis, Takayasu arteritis, IgG4-related disease) and less frequently in patients with syphilis or tuberculosis1. Aortitis is rarely suspected to be induced by drugs and its causality is hardly assessable. The aim of our study is to identify drugs associated with aortitis occurrence using a data-mining approach.We used VigiBase, the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database, which contains reports of suspected adverse drug reactions (ADR) collected by national drug authorities in more than 130 countries. The database is automatically deduplicated by VigiBase; further, a case-by-case review has been performed to exclude possible duplicates. This makes it powerful for the conduct of disproportionality analyses. This pharmacovigilance statistical method, based on a case/non-case approach, estimates whether an adverse event is differentially reported for a drug compared to other drugs. The association can be expressed using the reporting OR (ROR) and its CI for each drug adverse event combination. This approach has proven its interest for the detection of safety signals2. To identify drugs associated with aortitis occurrence, we extracted ICSR recorded in VigiBase from inception in 1967 until June 30, … Address correspondence to Prof. B. Terrier, Department of Internal Medicine, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. E-mail: benjamin.terrier{at}aphp.fr ER -