RT Journal Article
SR Electronic
T1 Characteristics of Takayasu Arteritis Patients with Severe Ischemic Events
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1224
OP 1228
DO 10.3899/jrheum.190407
VO 47
IS 8
A1 Richard Ying Yu
A1 Roaa AlSolimani
A1 Nader Khalidi
A1 Christian Pagnoux
A1 Lillian Barra
YR 2020
UL http://www.jrheum.org/content/47/8/1224.abstract
AB Objective. Takayasu arteritis (TA) is a rare large-vessel vasculitis that puts patients at high risk of developing severe ischemic events (SIE). Outcomes for TA patients with SIE are poorly understood. We aim to describe the characteristics of TA patients experiencing SIE.Methods. All TA patients with at least 1 followup visit seen between 1988 and 2015 were included from 3 academic centers in Ontario, Canada. Diagnosis was based on American College of Rheumatology criteria, physician opinion, and vascular imaging. SIE were defined as cerebrovascular accident (CVA), acute coronary syndrome (ACS), ischemic cardiomyopathy, ischemic blindness, and/or ischemic bowel or limb requiring surgery.Results. Of the 52 patients with TA included in the study, 51 (98%) were female and 22 (42%) were of European descent. The mean age was 31 (SD 12) at the time of diagnosis and the followup time was 6 years (SD 5). Fifteen (29%) experienced an SIE: 5 CVA, 5 ACS, 1 ischemic cardiomyopathy, and 4 limb ischemia. Thirteen out of 15 SIE (87%) occurred at or before diagnosis. Patients with SIE were more likely than those without SIE to be started on corticosteroids combined with immunosuppressants (p = 0.04) and antiplatelet agents (p = 0.004). Outcomes including disease activity and damage scores were similar between patients with and without SIE.Conclusion. SIE are common in patients with TA and occur early in the disease. With aggressive treatment, patients with SIE had a favorable prognosis.