RT Journal Article
SR Electronic
T1 Trends in the Inpatient Burden of Coronary Artery Disease in Granulomatosis with Polyangiitis: A Study of Large National Dataset
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.200374
DO 10.3899/jrheum.200374
A1 Yiming Luo
A1 Jiehui Xu
A1 Changchuan Jiang
A1 Chayakrit Krittanawong
A1 Lingling Wu
A1 Yifeng Yang
A1 Dhrubajyoti Bandyopadhyay
A1 Peter Cram
A1 Said Ibrahim
A1 Bella Mehta
YR 2020
UL http://www.jrheum.org/content/early/2020/06/09/jrheum.200374.abstract
AB Objective Cardiovascular diseases are serious comorbidities in patients with granulomatosis with polyangiitis (GPA). In a sample of patients hospitalized for GPA, we sought to examine trends in the burden of coronary artery disease (CAD) and its two serious manifestations, acute myocardial infraction (AMI) and heart failure (HF). Methods We used the National Inpatient Sample to conduct a retrospective cross-sectional analysis. Our sample consisted of hospitalizations for GPA between 2005 and 2014. We examined trends in the proportion of CAD, AMI, and HF in all hospitalizations with GPA compared to those without GPA. We used logistic regression adjusted for potential confounders and included interaction terms. Results Among a total of 103,453 GPA hospitalizations, 20,351 (19.7%) hospitalizations had a concurrent diagnosis of CAD. GPA with CAD was associated with overall lower burden of traditional cardiovascular risk factors compared to non-GPA with CAD, except chronic kidney disease (57% vs 21%). Over the 10-year study period, there were rising trends in the inpatient burden of CAD (from 16.6% in 2005 to 22.7% in 2014) and CAD with HF (from 4.31% in 2005 to 9.88% in 2014), but not AMI (from 1.17% in 2005 to 1.11% in 2014) in GPA hospitalizations compared to non-GPA controls. Conclusion In this national sample of GPA hospitalizations, we found that the burden of CAD and CAD with HF was on the rise over the 10-year period compared to non-GPA, however it was not the case for AMI.