PT  - JOURNAL ARTICLE
AU  - Anna Postolova
AU  - Megan L. Troxell
AU  - Irene L. Wapnir
AU  - Mark C. Genovese
TI  - Methotrexate in the Treatment of Idiopathic Granulomatous Mastitis
AID  - 10.3899/jrheum.181205
DP  - 2020 Jun 01
TA  - The Journal of Rheumatology
PG  - 924--927
VI  - 47
IP  - 6
4099  - http://www.jrheum.org/content/47/6/924.short
4100  - http://www.jrheum.org/content/47/6/924.full
SO  - J Rheumatol2020 Jun 01; 47
AB  - Objective. Idiopathic granulomatous mastitis (IGM) is a disfiguring inflammatory breast disease without effective treatment. We report the largest IGM cohort treated with methotrexate (MTX) monotherapy.Methods. Chart review was performed on patients evaluated by the Stanford Immunology and Rheumatology Clinic, with histopathologically established IGM treated with MTX, and at least 1 followup appointment.Results. Nineteen female patients with a mean age of 33.5 years were identified. Most failed treatment with antibiotics, prednisone, and surgical intervention. By 15 months of treatment with MTX, 94% had disease improvement and 75% achieved disease remission.Conclusion. MTX monotherapy is an effective treatment for IGM.