RT Journal Article
SR Electronic
T1 Development of a Scoring Tool for Chronic Nonbacterial Osteomyelitis Magnetic Resonance Imaging and Evaluation of its Interrater Reliability
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.190186
DO 10.3899/jrheum.190186
A1 Yongdong Zhao
A1 T. Shawn  Sato
A1 Sabrina M.  Nielsen
A1 Meinrad Beer
A1 Mingqian Huang
A1 Ramesh S.  Iyer
A1 Michael McGuire
A1 Anh-Vu Ngo
A1 Jeffrey P.  Otjen
A1 Jyoti Panwar
A1 Jennifer Stimec
A1 Mahesh Thapa
A1 Paolo Toma
A1 Angela Taneja
A1 Nancy E.  Gove
A1 Polly J.  Ferguson
YR 2019
UL http://www.jrheum.org/content/early/2020/01/10/jrheum.190186.abstract
AB Objective Serial magnetic resonance imaging (MRI) examinations are often needed in chronic nonbacterial osteomyelitis (CNO) to determine the objective response to treatment. Our objectives in this study were (1) to develop a consensus-based MRI scoring tool for clinical and research use in CNO; and (2) to evaluate interrater reliability and agreement using whole-body (WB)-MRI from children with CNO. Methods Eleven pediatric radiologists discussed definitions and grading of signal intensity, size of signal abnormality within bone marrow, and associated features on MRI through monthly conference calls and a consensus meeting, using a nominal group technique in July 2017. WB-MRI scans from children with CNO were deidentified for training reading and an interrater reliability study. The reading by each radiologist was conducted in a randomized order. Interrater reliability for abnormal signal and severity were assessed using free-marginal κ statistics. Results Radiologists reached a consensus on grading CNO-specific MRI findings and on describing bone units based on anatomy. A total of 45 sets of WB-MRI scans, including 4 sets of non-CNO MRI examinations, were selected for the final reading. The mean κ of each category of bones was > 0.7 with majority > 0.9 demonstrating substantial/almost perfect interrater reliability of readings among radiologists. The agreement on signal intensity and the size of signal abnormality within the most commonly affected bones (femur and tibia) were lower than those of other bones. Conclusion The chronic nonbacterial osteomyelitis magnetic resonance imaging scoring (CROMRIS) tool is a comprehensive standardized scoring tool for MRI in children with CNO. Our interrater study demonstrated good interrater reliability and agreement of readings.