PT  - JOURNAL ARTICLE
AU  - Sewerin, Philipp
AU  - Schleich, Christoph
AU  - Brinks, Ralph
AU  - Müller-Lutz, Anja
AU  - Fichter, Florian
AU  - Eichner, Markus
AU  - Schneider, Matthias
AU  - Ostendorf, Benedikt
AU  - Vordenbäumen, Stefan
TI  - Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging
AID  - 10.3899/jrheum.180832
DP  - 2020 Jan 01
TA  - The Journal of Rheumatology
PG  - 15--19
VI  - 47
IP  - 1
4099  - http://www.jrheum.org/content/47/1/15.short
4100  - http://www.jrheum.org/content/47/1/15.full
SO  - J Rheumatol2020 Jan 01; 47
AB  - Objective. To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).Methods. Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.Results. Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).Conclusion. Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.