RT Journal Article
SR Electronic
T1 Investigating the Association of Giant Cell Arteritis with Varicella Zoster Virus in Temporal Artery Biopsies or Ascending Aortic Resections
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1614
OP 1618
DO 10.3899/jrheum.180912
VO 46
IS 12
A1 Isaac H. Solomon
A1 William P. Docken
A1 Robert F. Padera Jr.
YR 2019
UL http://www.jrheum.org/content/46/12/1614.abstract
AB Objective. A variety of infectious agents, including varicella zoster virus (VZV), have been hypothesized to play a role in the pathogenesis of giant cell arteritis (GCA). The detectability of the virus in patients with GCA is debatable. To further investigate an association between GCA and VZV infection, 10 years of GCA cases were evaluated for VZV by immunohistochemistry (IHC).Methods. All temporal artery biopsies and ascending aortic resections positive for GCA from 2007 to 2017 at Brigham and Women’s Hospital were immunostained using a VZV antibody cocktail (SG1-1, SG1-SG4, NCP-1, and IE-62).Results. Forty-one temporal artery biopsies and 47 ascending aortic resections positive for GCA were identified, all of which were found to be negative for VZV by IHC. Twelve temporal artery biopsies in this cohort were previously analyzed by unbiased metagenomics sequencing and were negative for VZV DNA.Conclusion. These results argue against a clinically relevant association between VZV infection and GCA, and support neither routine testing for VZV nor treatment with antiviral drugs.